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Iolanda Panaitiu

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Articles signed on Romanian Journal of RHEUMATOLOGY:

VASCULOPATHY IN SYSTEMIC SCLEROSIS

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Romanian Journal of Rheumatology, Volume XXV, No. 2, 2016
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

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VASCULOPATHY IN SYSTEMIC SCLEROSIS

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ABSTRACT

Systemic sclerosis (SSc) is a complex, heterogeneous, multi-organ disease, the etiology of which is not yet fully understood. Although fibrosis of the skin and major organs is a well-known, characteristic sign of this condition, the primary dysfunctions contributing to the disease phenotype appear to be vascular and immune in nature. The mechanisms leading to vasculopathy in SSc include dysregulation of vascular tone and endothelial dysfunction, followed by vascular remodeling, as well as abnormal angiogenesis and vasculogenesis. In addition, coagulopathy also plays a role in the disease process. Together, these factors produce a form of vasculopathy specific to SSc, characterized by vascular intimal proliferation in the macro- and micro-circulation, as well as qualitative and quantitative capillary changes.

Keywords: vasculopathy, systemic sclerosis, immunopathogenesis, biomarkers

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