Author archives

Daniela Opris

Latest posts by Daniela Opris (see all)

Articles signed on Romanian Journal of RHEUMATOLOGY:

INFECTIA CRONICA CU VIRUSUL HEPATITIC C – MANIFESTARI SISTEMICE SI BOLI AUTOIMUNE ASOCIATE

SELECT ISSUE

Romanian Journal of Rheumatology, Volume XXIII, No. 4, 2014
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

INFECTIA CRONICA CU VIRUSUL HEPATITIC C – MANIFESTARI SISTEMICE SI BOLI AUTOIMUNE ASOCIATE

, , , , and

REZUMAT

Pacienţii cu infecţie cronică cu virus hepatitic C (VHC) pot prezenta o gamă largă de manifestări ca subfebră, astenie, fatigabilitate, artrite/artralgii, sindrom Sicca, mialgii, purpură, depresie sau titruri înalte de autoanticorpi. Acestea pot fi încadrate ca manifestări extrahepatice (MEH) ce însoţesc infecţia virală sau pot face parte din tabloul clinic al unei boli autoimune asociate.

Obiective. Studiul îşi propune descrierea prezenţei MEH a infecţiei cronice VHC şi a asocierii cu diverse boli autoimune în lotul studiat şi compararea diferitelor patternuri imunologice asociate.

Material şi metodă. S-a realizat un studiu descriptiv, transversal, pe un lot de pacienţi ce asociază hepatită cronică VHC şi o afecţiune reumatică, internaţi consecutiv într-o perioadă de 3 ani. S-au analizat MEH ca şi boală reumatică asociată ce i-a adus la medic. Pentru colectarea şi interpretarea datelor s-a folosit SPSS STATISTICS, corelaţia Pearson şi testul x2.

Rezultate. Studiul a inclus 91 (81,25%) de pacienţi de sex feminin şi 21 (18,75%) de pacienţi de sex masculin, predominând grupa de vârstă 51-60 de ani – 36 (32,14%) de pacienţi. 29 (25,89%) dintre pacienţii sub 60 de ani şi 38 (33,93%) dintre pacienţii peste 60 de ani prezintă MEH. 39 (40,42%) dintre MEH sunt reumatice (artrite/artralgii la 29 (72,5%) de pacienţi, sindrom Sicca – 8 (20%) pacienţi, crioglobulinemie 3 (7,5%) pacienţi), 14 (14,58%) endocrinologice (tiroidită Hashimoto – 7 (6,25%) pacienţi femei); diabet zaharat – 12 (13,18%) femei şi 5 (23,8%) – bărbaţi), 21 (28,12%) neuropsihice (neuropatie – 9 (9,89%) femei şi 1 (4,76%) bărbat, astenie fizică – 5 femei şi 1 bărbat, sindrom depresiv – 8 femei şi 1 bărbat), 5 (5,2%) dermatologice şi 11 (11,45%) pacienţi metabolici. Dintre bolile reumatice, pacienţii au asociat cel mai frecvent poliartrita reumatoidă – 36 (32,14%) de pacienţi, spon dilartrite 7 (6,25%) pacienţi, LES 4 (3,57%) pacienţi, scleroză sistemică şi boală Still întâlnindu-se la câte 2 (1,79%) pacienţi.

Concluzii. Prevalenţa manifestărilor extrahepatice la pacienţii cu infecţie cronică VHC este considerabilă. Diagnosticul diferenţial al afecţiunilor autoimune ce însoţesc infecţia virală este important, pacienţii trebuind astfel investigaţi complex şi trataţi multidisciplinar.

Cuvinte cheie: HCV, manifestări sistemice, boli autoimune

Full text | PDF

DISEASE ACTIVITY PREDICTS WHOLE BODY AND REGIONAL LEAN TISSUE IN RHEUMATOID ARTHRITIS – A CROSS-SECTIONAL STUDY

SELECT ISSUE

Romanian Journal of Rheumatology, Volume XXIV, No. 2, 2015
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

DISEASE ACTIVITY PREDICTS WHOLE BODY AND REGIONAL LEAN TISSUE IN RHEUMATOID ARTHRITIS – A CROSS-SECTIONAL STUDY

, , and

ABSTRACT

Aim. The study aims to assess the potential influences of rheumatoid arthritis (RA) and its specific disease measures on lean body composition phenotypes of female patients.

Methods. The study was cross-sectionally designed to include Caucasian postmenopausal female RA patients and age-matched postmenopausal female controls. All the subjects gave written informed consent and the study was approved by the local ethics committee. Each subject underwent in the same day a clinical examination, laboratory tests, whole body dual X-ray absorptiometry (DXA) composition and physical activity estimation using a self-administered questionnaire. Correlations, differences and predictive power were analyzed with appropriate statistical tests.

Results. The study included 107 RA patients and 104 controls. Compared to the normal subjects, who recorded higher levels of physical activity, the RA patients had significantly lower appendicular lean tissue absolute and relative indices and higher prevalence of sarcopenia. The whole body and appendicular lean tissue indices showed significant negative correlations with measures of disease severity (duration, inflammation, quality of life and radiographic progression), independent of age, levels of physical activity, body mass index and smoking.

Conclusions. The measures of disease activity and severity independently predict lean tissue phenotypes in RA patients, behaving as risk factors for sarcopenia and rheumatoid cachexia. The diagnosis of RA in itself is a significant predictive factor of sarcopenia.

Keywords: rheumatoid arthritis, dual X-ray absorptiometry, sarcopenia, cachexia

Full text | PDF