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Romanian Journal of Rheumatology, Volume XXV, No. 3, 2016
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791

Indexată BDI  |  IDB Indexed

DOAJ
Ebsco Host - Medline

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Committe on Publication Ethics

A forum for responsible and ethical research publishing – Code of Conduct and Best Practice Guidelines for Journal Editors.

PREMIU NAȚIONAL AUTORI

RJR și SRR oferă anual Premiul Național pentru Știință și Cercetare - pentru autorii celor mai bune articole științifice publicate [...]

Plagiatul – în actualitate

Tema plagiatului este tot mai mult discutată în ultima vreme. Apariția unor programe performante de căutare și identificare a similitudinilor între texte [...]

Successful outcome in a case of critical digital ischemia. Case report and literature analysis

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ABSTRACT

Critical digital ischemia (CDI) remains a distinct, serious complication of peripheral vasculopathy in systemic sclerosis, macrovascular as well as microvascular disease, abnormal vascular remodeling, vasoconstriction-vasodilation imbalance and fibrosis being key underlying factors. Successful short- as well as long-term outcomes may arise from early diagnosis, broad assessment and prompt therapeutic intervention. However, current treatment options are far from ideal, indicating the need for a complex approach focused on pathobiologic issues. We report the case of a middle age postmenopausal woman with a recent onset of CDI and subsequent gangrene, evolving in a very early PM-Scl positive systemic sclerosis. Dramatic improvement with complete resolution of CDI as well as healing of digital gangrene with minimal tissue loss was rapidly achieved under vasodilating therapy, after two cycles of intravenous prostanoids.

Keywords: critical digital ischemia, systemic sclerosis, anti-PM-Scl autoantibodies, prostanoids

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