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Romanian Journal of Rheumatology, Volume XXV, No. 3, 2016
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791

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HIGHLIGHTS

Society’s Prize for authors

Starting with 2016, The Romanian Society of Rheumatology offers Society’s Prize – for the authors who published the best scientific articles [...]

Plagiatul – in actualitate

Tema plagiatului este tot mai mult discutata in ultima vreme. Aparitia unor programe performante de cautare si identificare a similitudinilor intre texte [...]

Successful outcome in a case of critical digital ischemia. Case report and literature analysis

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ABSTRACT

Critical digital ischemia (CDI) remains a distinct, serious complication of peripheral vasculopathy in systemic sclerosis, macrovascular as well as microvascular disease, abnormal vascular remodeling, vasoconstriction-vasodilation imbalance and fibrosis being key underlying factors. Successful short- as well as long-term outcomes may arise from early diagnosis, broad assessment and prompt therapeutic intervention. However, current treatment options are far from ideal, indicating the need for a complex approach focused on pathobiologic issues. We report the case of a middle age postmenopausal woman with a recent onset of CDI and subsequent gangrene, evolving in a very early PM-Scl positive systemic sclerosis. Dramatic improvement with complete resolution of CDI as well as healing of digital gangrene with minimal tissue loss was rapidly achieved under vasodilating therapy, after two cycles of intravenous prostanoids.

Keywords: critical digital ischemia, systemic sclerosis, anti-PM-Scl autoantibodies, prostanoids

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