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Olivia Mihaela Popa

Latest posts by Olivia Mihaela Popa (see all)

  • THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS - 07/08/2016
  • INTERLEUKIN 1A GENE POLYMORPHISMS IN ROMANIAN PATIENTS WITH SERONEGATIVE SPONDYLOARTHROPATHIES - 10/05/2016
  • ENDOPLASMIC RETICULUM AMINO PEPTIDASE 1 (ERAP1) IN ANKYLOSING SPONDYLITIS - 21/09/2015

Articles signed on Romanian Journal of RHEUMATOLOGY:

THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS

SELECT ISSUE

Romanian Journal of Rheumatology, Volume XXV, No. 2, 2016
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

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National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

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Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

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THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS

Laura Ioana Cherciu, Marius Cherciu, Luis Ovidiu Popa, Mihai Bojinca, Monica Irina Dutescu, Violeta Bojinca, Constantin Bara and Olivia Mihaela Popa

ABSTRACT

Objective. Our aim was to investigate whether two ERAP2 single nucleotide polymorphisms (rs2910686 and rs2248374) influence spondyloarthritis (SpA) susceptibility in Romanians.
Methods. The case control study included 139 controls and 192 SpA patients. The two polymorphisms were genotyped by real time polymerase chain reaction (RT-PCR). The association tests for allele, genotype and haplotype frequencies for each polymorphism were performed with PLINK 1.9.
Results. The genotypes and allele frequencies of the two SNPs in general SpA group vs. controls showed no association except for a possible marginal one for the minor allele A of rs2248374 (p = 0.08). In HLA-B27 negative SpA cohort the minor allele (A) frequency (55.4%) of SNP rs2248374 was significantly higher than the one in HLA-B27 controls (44.5%) (p = 0.012). HLA-B27 negative carriers of minor allele A present a higher risk of developing SpA (p = 0.015). Also for the second ERAP2 gene variant investigated (rs2910686) the minor allele T frequency was significantly higher (46.5%) in HLA-B27 negative SPA patients when compared with HLA-B27 negative controls (36%) (p = 0.02). The haplotype of the minor alleles (AC) is a risk factor for HLA-B27 negative SpA (p = 0.019), while the haplotype of the major alleles (GT) is a protective one against the disease in HLA-B27 negative cohorts (p = 0.009).
Conclusions. Both ERAP2 gene polymorphisms investigated, especially rs2248374, influence SpA susceptibility, but this influence is limited only to the HLA-B27 negative individuals.

Keywords: ERAP2 gene, seronegative spondyloarthropathies (SpA), human leukocyte antigen (HLA)-B27, single nucleotide polymorphisms (SNPs)

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INTERLEUKIN 1A GENE POLYMORPHISMS IN ROMANIAN PATIENTS WITH SERONEGATIVE SPONDYLOARTHROPATHIES

SELECT ISSUE

Romanian Journal of Rheumatology, Volume XXV, No. 1, 2016
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
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NLM Catalog
Ebsco Host - Medline
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Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

INTERLEUKIN 1A GENE POLYMORPHISMS IN ROMANIAN PATIENTS WITH SERONEGATIVE SPONDYLOARTHROPATHIES

Laura Ioana Cherciu, Marius Cherciu, Luis Ovidiu Popa, Mihai Bojinca, Monica Irina Dutescu, Violeta Bojinca, Constantin Bara and Olivia Mihaela Popa

ABSTRACT

Objective. The aim of this study was to investigate whether two IL1A gene polymorphisms, rs17561 and rs1800587, influence disease susceptibility for seronegative spondyloarthropathies (SpA) in Romanians. Subsequently, we analysed separately ankylosing spondylitis (AS) and psoriatic arthritis (PsA) subgroups in relation with the two IL1A gene variants.

Methods. The study included 240 SpA patients (140 AS and 100 PsA patients) and 160 healthy controls. Real-time polymerase chain reaction (RT-PCR) was used to genotype the two single nucleotide polymorphisms (SNPs). Allele, genotype and haplotype frequencies of each SNP were compared between SpA patients and controls and also between AS and PsA cohorts and controls. The PLINK 1.9 software package was used to assess the potential associations; p values ≤ 0.05 were considered significant.

Results. The minor allele T frequency for rs17561 polymorphism was similar in general SpA cohort (31.4%) compared with controls (32.8%), the statistical analyses confirming the lack of association (p=0.67). Almost identical results were found for rs1800587: minor allele T frequency was 29.1% in SpA patients and 29.7% in controls (p=0.85). The same pattern persisted for the separate analysis of HLA-B27 positive SpA patients or AS and PsA cases against controls.

Conclusions. The IL1A gene polymorphisms (rs17561 and rs1800587) do not influence the disease predisposition for seronegative spondyloarthropathies in general, nor for ankylosing spondylitis and psoriatic arthritis in particular, in Romanians.

Keywords: IL1A gene, seronegative spondyloarthropathies (SpA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), single nucleotide polymorphisms (SNPs)

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ENDOPLASMIC RETICULUM AMINO PEPTIDASE 1 (ERAP1) IN ANKYLOSING SPONDYLITIS

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Romanian Journal of Neurology, Volume XXIV, No. 1, 2015
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
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HIGHLIGHTS

National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ENDOPLASMIC RETICULUM AMINO PEPTIDASE 1 (ERAP1) IN ANKYLOSING SPONDYLITIS

Marius Cherciu, Mihai Bojinca, Laura Ioana Cherciu, Constantin Bara and Olivia Mihaela Popa

ABSTRACT

Recently, endoplasmic reticulum aminopeptidase 1 (ERAP1) gene polymorphisms were associated with ankylosing spondylitis (AS) in genome-wide association studies (GWAS), associations which later were replicated across different populations, including the Romanian population. ERAP1 enzyme was proved to be involved in the final trimming, to the optimal length, of the antigenic peptides before loading them to human leucocyte antigen (HLA) class I molecules, different variants of ERAP1 being able to modify the types of peptides presented by HLA I molecules (including HLA-B27) to the CD8+ T cells. This article presents a detailed description of the functions, structure and the pathogenic potential of ERAP1 in AS.

Keywords: ERAP1, ankylosing spondylitis, HLA-B27, single nucleotide polymorphisms (SNPs)

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INTERLEUKIN (IL) 12, IL-23 AND IL-23 RECEPTOR IN ANKYLOSING SPONDYLITIS PATHOPHYSIOLOGY

SELECT ISSUE

Romanian Journal of Neurology, Volume XXIV, No. 1, 2015
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

INTERLEUKIN (IL) 12, IL-23 AND IL-23 RECEPTOR IN ANKYLOSING SPONDYLITIS PATHOPHYSIOLOGY

Marius Cherciu, Laura Ioana Cherciu, Mihai Bojinca, Teodora Serban, Constantin Bara and Olivia Mihaela Popa

ABSTRACT

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis which involves mainly the spine and the sacroiliac joints, but also the peripheral joints and nonarticular structures. IL-12 and IL-23 are heterodimeric cytokines sharing a common p40 subunit. Studies showed than IL-12 is essential for Th1 differentiation while IL-23 promotes a particular subset of T cells characterized by IL-17 production, called Th17. Since the association of IL-23R with AS was reported, the scientific interest has focused on identifying new single nucleotide polymorphisms (SNPs), present in the coding genes for IL-12/IL-23 subunits and their receptors, that increase the susceptibility for AS. Another point of interest for researchers was to investigate if the identified gene variants modify the gene expression of the respective interleukins and/or their receptors, whether that refers to their mRNA expression, their serum levels or the expression of the receptors on the surface of T cells. Given the increasing amount of data that suggests the pivotal role of the IL-23/Th17 axis in AS pathophysiology, new promising therapies, designed to interfere with these pathways, are now in development.

Keywords: IL-12, IL-23, IL-23R, ankylosing spondylitis, single nucleotide polymorphisms (SNPs)

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ERAP1 GENE POLYMORPHISMS INFLUENCE THE CLINICAL CHARACTERISTICS OF ANKYLOSING SPONDYLITIS

SELECT ISSUE

Romanian Journal of Rheumatology, Volume XXIV, No. 2, 2015
ISSN 1843-0791  |  e-ISSN 2069-6086
ISSN-L 1843-0791
DOI: 10.37897/RJR

Indexed

DOI - Crossref
Similarity Check by iThenticate, worldwide No 1 professional plagiarism checking system
DOAJ
Scopus
NLM Catalog
Ebsco Host - Medline
Google Academic
Semantic Scholar

HIGHLIGHTS

National Awards “Science and Research”

NEW! RJR has announced the annually National Award for "Science and Research" for the best scientific articles published throughout the year in the official journal.

ICMJE- Recommendations

Read the Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly work in Medical Journals.

Promoting Global Health

The published medical research literature is a global public good. Medical journal editors have a social responsibility to promote global health by publishing, whenever possible, research that furthers health worldwide.

ERAP1 GENE POLYMORPHISMS INFLUENCE THE CLINICAL CHARACTERISTICS OF ANKYLOSING SPONDYLITIS

Marius Cherciu, Luis Ovidiu Popa, Mihai Bojinca, Monica Irina Dutescu, Violeta Bojinca, Teodora Serban, Constantin Bara and Olivia Mihaela Popa

ABSTRACT

Objective. Our aim was to investigate whether two ERAP1 gene variants, rs30187 and rs27044, influence the clinical characteristics of ankylosing spondylitis (AS) (the age of onset and the type of articular manifestations - axial or mixed) in Romanian patients.

Methods. We studied 94 AS patients and 139 healthy controls. The method used for genotyping the two nonsynonymous single nucleotide polymorphisms (SNPs) was real-time polymerase chain reaction. Association tests were carried out using PLINK 1.07 software. We analyzed separately the subgroups of AS patients with early onset (age <30 years) and late onset (age > 30 years), as well as the subgroups of patients with axial manifestations and mixed manifestations (axial and peripheral).

Results. Significant association between ERAP1 polymorphisms and AS is only present for patients who experienced an early onset (p = 0.04 for rs30187 and p = 0.007 for rs27044) and not for those with late onset (p = 0.32 for rs30187 and p = 0.29 for rs27044). Polymorphism rs30187 is associated only with the axial form of AS (p = 0.02), while rs27044 is associated only with the mixed form of the disease (p = 0.02)

Conclusions. Our findings demonstrate a consistent association between the studied ERAP1 gene SNPs and certain phenotypic characteristics of AS, suggesting that these gene variants may influence the AS onset and the presence of axial or mixed manifestations of AS.

Keywords: ERAP1, ankylosing spondylitis, single nucleotide polymorphisms (SNPs), age of onset, clinical characteristics

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